How to sign: afflicted with or marked by anxious uneasiness or trouble or grief
"too upset to say anything"; "spent many disquieted moments"; "distressed about her son's leaving home"; "lapsed into disturbed sleep"; "worried parents"; "a worried frown"; "one last wo;
Similiar / Same: disquieted, upset, worried, distressed
How to sign: affected with madness or insanity
"a man who had gone mad";
Similiar / Same: brainsick, crazy, demented, unhinged, mad, unbalanced, sick